|Pfeiffer Syndrome involves premature
cranial vault synostosis of both coronal sutures,
whereas in Crouzon Syndrome other sutures may be the
culprit. Like Crouzon Syndrome, however, Pfeiffer
Syndrome causes midface hypoplasia. Pfeiffer Syndrome is
also identified by unusually wide thumbs and fusion of
the soft and/or connective tissue in the hands.